Visit In the Pipeline

Another Alzheimer's Compound Goes Down

Posted on June 30, 2008

I was mentioning the gamma secretase enzyme around here just the other day as a longstanding target for Alzheimer's therapy. I remember the periodduring the 1990s when the enzyme hadn't been identified yet, and frankly, it was a lot easier to get excited about it then. That's because when it was finally worked out, the protease turned out to be a big multifunctional multiprotein complex, and among its many functions was affecting Notch signaling.That's worrisome, because a lot of important cellular development pathways go through the Notch receptor, and these are things that you'd really rathe...

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enzyme , phase