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Protecting Amyloid's Parent?

Posted on June 17, 2008

Let s start from first principles: most drugs mess something up. More elegantly, most drugs inhibit some enzyme s activity or block some receptor s binding site. Proteins are generally pretty well optimized at what they do, so it s a lot easier to block their activities than it is to speed them up. (There are rare exceptions).And if you re going to target an enzyme with a small molecule inhibitor, you ll do just that find a small molecule that fits into the active site of the enzyme and gums up the works. In a few cases, we know of drugs that bind to other sites on the protein ...

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disease , enzyme , protein