Visit In the Pipeline

Up Close and Personal

Posted on May 23, 2008

Something that s come up in the last few posts around here is the way that we chemists think about the insides of enzymes. It s a tricky subject, because when you picture things on that scale, the intuition you have for objects starts to betray you.Consider water. We humans have a pretty good practical understanding of how water behaves in the bulk phase; we have the experience. But what about five water molecules sitting in the pocket of an enzyme? That s not exactly a glass from the tap. These guys are interacting with the protein as much (or more) than they re interacting with each ...

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enzyme , phase , protein