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Genetic Test Predicts Response to Warfarin

Posted on March 06, 2008

That information already is being put to medical use. Last August, the U.S. Food and Drug Administration changed the labeling to say that doctors should consider a genetic test when first prescribing warfarin, better known by its brand name, Coumadin.But warfarin is a notoriously difficult drug to manage, especially at the start. Too much can lead to hemorrhages; too little can allow clots to form. One individual may do well on 1.5 milligrams a day, while another may require 20 milligrams daily.Two genes are known to affect the response to warfarin. One, designated CYP2C9, governs the metaboli...

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